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It stimulates the heart to diffuse the blood uniformly throughout the entire capillary circulation, and thus prevents cerebral engorgement. Combined with cimicifuga, the value of both these agents is increased in their adaptability to chorea. Permeability dominates in vivo intestinal absorption of P-gp substrate with high solubility and high permeability. Further, it isapparent that the calcium channels might be re- sponsible, on occasion, for localized areas of slowconductioninthe ventricles. Photoprotective effects were also reported for topical application of several other substances with antioxidant properties. The treatment goal of medical therapy is to achieve a diastolic blood pressure less than 110 mmHg, and in the range of 90–100 mmHg. Considering the millions of women who have used Bendectin during the first trimester of pregnancy without scientific evidence of adverse fetal effects, it is extremely unlikely that doxy- lamine or the components of Bendectin are human teratogens. General Cardiovascular Risk Profile for use in Primary Care: The Framingham Heart Study. A similar mechanism involving Gi protein inhibition of adenylyl cyclaseoccurs with activation of M2 receptors (see answer 6). In fact, careful quantitative analysis of the order of activity of the agonists in each test, and of the precise potency of antagonists (see Chapter 5 for quantitative detail) has often successfully indicated, although rarely proved, the presence of subclasses of a receptor type (e. Although metabolites of clorazepate dipotassium generally create the medical actions, for simplicity this discussion usually refers only to the pro- drug clorazepate dipotassium and calls it a drug. 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