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DYE STUFFS IN MEDICINE.
A coal tar dye is popularly regarded as an aniline
dye, but this w-e paydirt slot machine know is not true, for picric acid,
aurin, eosin, alizarin, indigo, anthrapurpurin. and
many other important coloring matters are, strictly
speaking, coal tar dyes, though they cannot be de-
scribed as aniline dyes. All colored organic com-
pounds, such as the quinones, azobenzol derivatives.
nitro compounds, etc., are decolorized by reducing
agents, and from this we are to infer that "the
coloring matters paydirt slots free contain elements with incomplete-
ly saturated affinities, or that certain of the atoms
are present in more intimate association than their
retention in the molecule necessitates." These color-
ing matters are acted upon by salt forming groups,
and upon the nature of these groups depends the
character of the coloring matter. In the same man-
ner color giving groups are treated with substitu-
tion groups in order to form compounds of me-
dicinal or therapeutic value.
Spectroscopic paydirt slot machine free games investigations show that no open
chain hydrocarbon paydirt slot machine free causes selective absorption, but
that benzol, QH^, and allied hydrocarbons are char-
acterized by selective absorption of the most re-
frangible rays and are thereby distinguished from
all other classes. It may be stated that benzol has
invisible color which will become visible when the
rate of vibration is so slackened that it is possible
for the molecule to absorb ravs having an oscilla-
tion frequency occurring within the limits of visi-
bility. Phenol shows selective absorption in the ul-
tra violet region, but the replacement of three hy-
drogen atoms by three nitro groups gives the yel-
low picric acid. The mere fact that an aromatic
substance is colored or has dyeing properties does
not necessarily mean that it will in consequence
show any novel pharmacological action.
Ehrlich paydirt slot free download employed the aromatic dyes to elucidate
the distribution of poisons and drugs in the animal
body, or, rather, to throw light on the selective ac-
tion of the cells. From observations of this char-
acter Ehrlich deduced the hypothesis that the vari-
ous cells of the body took up different chemical
substances in a greater or less degree according to
their chemical environment. Observations on the
physiological action of the organic dye stuffs have
also of recent years begun to show results of prac-
tical value, and it is quite possible that important
developments in therapeutics may result from a fur-
ther study of these derivatives. Many possess a
remarkable bactericidal action and it has been pos-
sible to employ them against some of the infections.
The parasitic trypanosomata have been shown to
be decidedly influenced, both in experimental paydirt slot machine download ani-
mals and in man, by treatment with certain dye
stuffs, such as malachite green and trypan blue.
The introduction of the nitro group into phenolic
substances increases the antiseptic and toxic action.
Both are powerful blood poisons and respiratorj' de-
pressants, especially dinitrocresol, possibly owing to
its greater solubility. The group of naphthol nitro
derivatives includes ]\Iartin's yellow, which is simi-
lar in its action to dinitrocresol. The azo dyes are
a class of substances which contain as chromophore
the group N = N. The simplest azo dyes are yel-
low, and their tint is first dependent on the nature
of the free paydirt slot machine auxochrome group, and secondly, on that of
the carbon complex. They may be made to pass
through red to violet and in certain instances to
brown. Those containing the benzol nucleus are
yellow, orange, and brown ; those containing the
naphthaleine are red. Trypan red is a benzidene
dye obtained from benzidenemonosulphonic acid by
diazotization and combination with the sodium salt
of the disulphonic acid of betanaphthylamine. Ehr-
lich and Shiga experimented with this substance on
mice infected with trypanosomiasis. One per cent.
solutions were injected subcutaneously in quantities
of from 0.5 to 1 .0 c.c. They had a very marked
though temporary destructive action on the para-
sites. Animals after cure were protected to a great
extent against a second infection.
Trypan blue, though differing in its cliemic;il paydirt slots
constitution, has an action similar to that of trypan
red on the tr\nanosomes. Ehrlich states that strains
rendered resistant to the one are also immune to
the other, though they may be destroyed by fuch-
sin or atoxyl. He possesses a strain of trypano-
somes which are resistant to all these agents. Thus,
if a mouse infected with this strain is cured by a
new drug, the latter cannot belong to one of these
agents, trypan red or blue.
Pyoctanin and malachite green have been em-
ployed by Wendestadt to destroy the trypano-
somes of the tsetse fly disease. They have also been
employed by F. Loeffler for separating colonies of
Bacillus coli and the bacillus of typhoid fever. The
growth of the former organism was prevented by
an admixture of this dye with the culture medium,
the colonies of the latter remaining unaffected.
Methyl violet is a paydirt slots online mixture of the hydrochlorides of
the he.xamethyl pararosanilines. paydirt slots play for fun Methyl violet is a
more powerful antiseptic than the yellow pyoctanin.
but relatively less toxic. It has been used locally
for inoperable cancer, A large number of similar
derivatives have been studied and found to have
antiseptic properties which differ but slightly from
those of the parent dyes.
The antiseptic power of these bodies has not been
shown to be in direct relation to their staining prop-
erties, but appears to depend upon the presence of
the aromatic nuclei. Eosin, the alkali salt of tetra-
bromfluorescein, has been shown by Noguchi to
have the power of neutralizing certain toxic sub-
stances occurring in cobra and other snake venoms.
Methylene blue has been tried in malaria, but does
not compare favorably with quinine. In large doses
it is a powerful irritant. Gautrelet and Bernard
have showoi that in rabbits it causes a fall in urea
excretion and some decrease in the activity of the
kidneys. Philadelphia yellow is a powerful proto-
plasmic poison, especially for the protozoan. It is
a local irritant. It has been tried as a substitute for
quinine in malaria, but does not seem to have been
efficient. It is absorbed from the stomach with dif-
ficulty. Scarlet red, a very brilliant scarlet dye, is
made by the action of diazobenzoldisulphonic acid
upon betanaphthol ; it has the singular property of
producing atypical epithelial proliferation and has
therefore been successfully employed in the treat-
ment of indolent ulcers.
THE H.\RM OF PUBLICITY'.
We have always deplored the undue exploitation
of medical topics in the newspaper press. Our atti-
tude in this matter has not infrequently been con-
demned by newspaper editors as narrow and selfish,
but this condemnation has been based on a miscon-
ception of our views and of oyr reasons for holding
these views. Ft is of course desirable, even neces-
sary, for newspapers and magazines to help educate
the public in matters of prophylaxis and sanitation.
The lay press has done and is doing great service
to the community in this direction, but that service
is offset to a certain extent by the not infrequent
excursions of the nonmedical writer into fields with
which he is not familiar and in which he might do